Study on optimizing high-gradient magnetic separation — Part 1: Improvement of magnetic particle retention based on CFD simulations

  • The introduction of functionalized magnetizable particles for the purification of enzymes or for the multi-use of pre-immobilized biocatalysts offers a great potential for time and cost savings in biotechnological process design. The selective separation of the magnetizable particles is performed for example by a high-gradient magnetic separator. In this study FEM and CFD simulations of the magnetic field and the fluid flow field within a filter chamber of a magnetic separator were carried out, to find an optimal separator design. The motion of virtual magnetizable particles was calculated with a one-way coupled Lagrangian approach in order to test many geometric and parametric variations in reduced time. It was found that a flow homogenisator smoothed the fluid flow, so that the linear velocity became nearly equal over the cross section in the direction of flow. Furthermore the retention of magnetizable particles increases with a high total edge length within the filter matrix.

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Author:Yonas S. ShaikhORCiD, Christian Seibert, Percy Kampeis
Parent Title (English):World Journal of Condensed Matter Physics
Publisher:Scientific Research Publishing
Document Type:Article (specialist journals)
Date of OPUS upload:2023/02/28
Date of first Publication:2016/05/31
Publishing University:Hochschule Trier
Release Date:2023/02/28
Tag:biocatalysis; computational fluid dynamics; enzyme purification; finite element method; high-gradient magnetic separator; magnetic filtration; magnetic particles
GND Keyword:Biotechnik; Numerische Strömungssimulation; Finite-Elemente-Methode; Magnetische Eigenschaft; Magnetisches Trennverfahren; Magnetabscheider; Magnetisierung; Biokatalyse; Enzym; Reinigungsverfahren
Page Number:14
First Page:123
Last Page:136
Departments:Institute / IBioPD - Institut für biotechnisches Prozessdesign
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 60 Technik
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International