TY - JOUR A1 - Shaikh, Yonas S. A1 - Seibert, Christian A1 - Kampeis, Percy T1 - Study on optimizing high-gradient magnetic separation — Part 1: Improvement of magnetic particle retention based on CFD simulations T2 - World Journal of Condensed Matter Physics N2 - The introduction of functionalized magnetizable particles for the purification of enzymes or for the multi-use of pre-immobilized biocatalysts offers a great potential for time and cost savings in biotechnological process design. The selective separation of the magnetizable particles is performed for example by a high-gradient magnetic separator. In this study FEM and CFD simulations of the magnetic field and the fluid flow field within a filter chamber of a magnetic separator were carried out, to find an optimal separator design. The motion of virtual magnetizable particles was calculated with a one-way coupled Lagrangian approach in order to test many geometric and parametric variations in reduced time. It was found that a flow homogenisator smoothed the fluid flow, so that the linear velocity became nearly equal over the cross section in the direction of flow. Furthermore the retention of magnetizable particles increases with a high total edge length within the filter matrix. KW - computational fluid dynamics KW - finite element method KW - magnetic particles KW - high-gradient magnetic separator KW - magnetic filtration KW - biocatalysis KW - enzyme purification KW - Biotechnik KW - Numerische Strömungssimulation KW - Finite-Elemente-Methode KW - Magnetische Eigenschaft KW - Magnetisches Trennverfahren KW - Magnetabscheider KW - Magnetisierung KW - Biokatalyse KW - Enzym KW - Reinigungsverfahren Y1 - 2016 UR - https://hst.opus.hbz-nrw.de/frontdoor/index/index/docId/250 UR - https://nbn-resolving.org/urn:nbn:de:hbz:tr5-2501 VL - 6 IS - 2 SP - 123 EP - 136 PB - Scientific Research Publishing ER -