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PaCER - A fully automated method for electrode trajectory and contact reconstruction in deep brain stimulation

  • Deep brain stimulation (DBS) is a neurosurgical intervention where electrodes are permanently implanted into the brain in order to modulate pathologic neural activity. The post-operative reconstruction of the DBS electrodes is important for an efficient stimulation parameter tuning. A major limitation of existing approaches for electrode reconstruction from post-operative imaging that prevents the clinical routine use is that they are manual or semi-automatic, and thus both time-consuming and subjective. Moreover, the existing methods rely on a simplified model of a straight line electrode trajectory, rather than the more realistic curved trajectory. The main contribution of this paper is that for the first time we present a highly accurate and fully automated method for electrode reconstruction that considers curved trajectories. The robustness of our proposed method is demonstrated using a multi-center clinical dataset consisting of N = 44 electrodes. In all cases the electrode trajectories were successfully identified and reconstructed. In addition, the accuracy is demonstrated quantitatively using a high-accuracy phantom with known ground truth. In the phantom experiment, the method could detect individual electrode contacts with high accuracy and the trajectory reconstruction reached an error level below 100 μm (0.046 ± 0.025 mm). An implementation of the method is made publicly available such that it can directly be used by researchers or clinicians. This constitutes an important step towards future integration of lead reconstruction into standard clinical care.

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Metadaten
Verfasserangaben:Andreas HuschORCiD, Mikkel V. Petersen, Peter GemmarORCiD, Jorge Goncalves, Frank Hertel
URN:urn:nbn:de:hbz:tr5-1767
DOI:https://doi.org/10.1016/j.nicl.2017.10.004
Titel des übergeordneten Werkes (Englisch):NeuroImage: Clinical
Verlag:Elsevier
Dokumentart:Wissenschaftlicher Artikel (Fachzeitschriften)
Sprache:Englisch
Datum des OPUS-Uploads:15.11.2022
Jahr der Erstveröffentlichung:2018
Veröffentlichende Hochschule:Hochschule Trier
Datum der Freischaltung:15.11.2022
Freies Schlagwort / Tag:curved trajectory; deep brain stimulation; electrode reconstruction
GND-Schlagwort:Hirnstimulation; Elektrode
Jahrgang:17
Seitenzahl:10
Erste Seite:80
Letzte Seite:89
Einrichtungen:FB Informatik + Therapiewissenschaft
DDC-Klassifikation:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit
Lizenz (Deutsch):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International