TY  - JOUR
A1  - Bremm, Rene Peter
A1  - Koch, Klaus P.
A1  - Krüger, Rejko
A1  - Goncalves, Jorge
A1  - Hertel, Frank
T1  - Analysis and visualisation of tremor dynamics in deep brain stimulation patients
T2  - Current Directions in Biomedical Engineering
N2  - Deep brain stimulation (DBS) is an established therapy for movement disorders such as in Parkinson's disease (PD) and essential tremor (ET). Adjusting the stimulation parameters, however, is a labour-intensive process and often requires several patient visits. Physicians prefer objective tools to improve (or maintain) the performance in DBS. Wearable motion sensors (WMS) are able to detect some manifestations of pathological signs, such as tremor in PD. However, the interpretation of sensor data is often highly technical and methods to visualise tremor data of patients undergoing DBS in a clinical setting are lacking. This work aims to visualise the dynamics of tremor responses to DBS parameter changes with WMS while patients performing clinical hand movements. To this end, we attended DBS programming sessions of two patients with the aim to visualise certain aspects of the clinical examination. PD tremor and ET were effectively quantified by acceleration amplitude and frequency. Tremor dynamics were analysed and visualised based on setpoints, movement transitions and stability aspects. These methods have not yet been  employed and examples demonstrate how tremor dynamics can be visualised with simple analysis techniques. We therefore provide a base for future research work on visualisation tools in order to assist clinicians who frequently encounter patients for DBS therapy. This could lead to benefits in terms of enhanced evaluation of treatment efficacy in the future.
KW  - wearable motion sensors
KW  - movement disorders
KW  - tremor
KW  - deep brain stimulation
KW  - spectral estimation
KW  - Hirnstimulation
KW  - Bewegungsstörung
KW  - Essenzieller Tremor
KW  - Parkinson-Krankheit
KW  - Bewegung
KW  - Sensor
Y1  - 2020
UR  - https://hst.opus.hbz-nrw.de/frontdoor/index/index/docId/260
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:tr5-2600
VL  - 6
IS  - 3
SP  - 1
EP  - 4
PB  - De Gruyter
ER  -